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Publikationer

Lifetime risk of solid tumors and leukemia in Down Syndrome: a population-based Swedish matched cohort study.

Wachtmeister A, Bang B, Nordgren I, Martling A, Johansson B, Lu Y, Skarin Nordenvall A, Tettamanti G, Nordgren A.Br J Cancer. 2025 Dec 26. doi: 10.1038/s41416-025-03318-5. Online ahead of print.PMID: 41454185

Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma.

Radke K, Aaltonen K, Muciño-Olmos EA, Esfandyari J, Adamska A, Siaw JT, Adamic D, Lago C, Mañas A, Seger A, Hansson K, Rogova O, Lehn S, Mason DJ, O'Donovan DJ, Roberts I, Lock A, Brennan J, Pietras K, Davies EJ, Spégel P, Bedoya-Reina OC, Brown D, Thompson NT, Spadoni C, Bexell D.EMBO Mol Med. 2025 Dec 23. doi: 10.1038/s44321-025-00349-6. Online ahead of print.PMID: 41437160 Free article.

Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma.

Braun S, Bolivar P, Oudenaarden C, Sjölund J, Bocci M, Harbst K, Talkhoncheh MS, Phung B, Cordero E, Rosberg R, Johansson E, Jönsson GB, Pietras A, Pietras K.Nat Commun. 2025 Dec 4;16(1):10918. doi: 10.1038/s41467-025-66985-1.PMID: 41339360 Free PMC article.

Comprehensive characterization and targeted treatment of a pediatric epithelioid glioblastoma with a rare TRIM24-NTRK2 fusion.

Keane S, Sjöberg I, Deland L, Lindlöf A, Bontell TO, Kling T, Blomstrand M, Fagman H, Nilsson JA, Nilsson D, Sabel M, Carén H, Abel F.NPJ Precis Oncol. 2025 Dec 2;9(1):394. doi: 10.1038/s41698-025-01190-3.PMID: 41331048 Free PMC article.

Overall Good Quality of Life Reported by Survivors of Childhood Hodgkin Lymphoma in Sweden and Finland.

Giertz M, Englund A, Fernsten F, Michelsen Wilk S, Niinimäki R, Harila A, Aarnivala H.Acta Paediatr. 2025 Nov 27. doi: 10.1111/apa.70386. Online ahead of print.PMID: 41307354

The AML cellular state space unveils NPM1 immune evasion subtypes with distinct clinical outcomes.

Lilljebjörn H, Peña-Martínez P, Thorsson H, Henningsson R, Rissler M, Landberg N, Puente-Moncada N, von Palffy S, Rissler V, Stanek P, Desponds J, Zhong X, Juliusson G, Lazarevic V, Lehmann S, Fontes M, Ågerstam H, Sandén C, Orsmark-Pietras C, Fioretos T.Nat Commun. 2025 Nov 25;16(1):10592. doi: 10.1038/s41467-025-66546-6.PMID: 41290664 Free PMC article.

Early Toxicity in Childhood Acute Lymphoblastic Leukemia: A Comparison of NOPHO ALL2008 and ALLTogether Protocols in Sweden.

Fermér J, van Bunningen H, Zhou O, Abrahamsson J, Borssen M, Donnér I, Heyman M, Holmqvist AS, Valind A, Vogt H, Ranta S, Harila A.Pediatr Blood Cancer. 2025 Nov 20:e32168. doi: 10.1002/pbc.32168. Online ahead of print.PMID: 41262029

An Exploration of Motion-Sampling Interactions in 3D MRI for Neuroimaging.

Schauman S, van Niekerk A, Norbeck O, Rydén H, Avventi E, Skare S.Magn Reson Med. 2025 Nov 7. doi: 10.1002/mrm.70132. Online ahead of print.PMID: 41204061

Patient-specific sequencing panels enable sensitive circulating tumor DNA analysis in rhabdomyosarcoma independent of genetic profile.

Rahmqvist I, Dahlstrand Rudin A, Mellström E, R Ibrahim R, Andersson D, Pujol Calderón F, Ordqvist Redfors A, Rostamzadeh N, Franssila W, Karlsson C, Zetterlund F, Khashan R, Frostdahl H, Österlund T, Ek T, Fagman H, Ståhlberg A, Dalin M.NPJ Precis Oncol. 2025 Oct 21;9(1):327. doi: 10.1038/s41698-025-01147-6.PMID: 41120703 Free PMC article. 

HIF2α negatively regulates MYCN protein levels and promotes a low-risk noradrenergic phenotype in neuroblastoma.

Yuan J, Maitra S, Antoniou E, Zhu J, Li W, Demirel IS, Toskas K, Martinez IL, Ozcimen L, Lindehell H, Muhr J, Stenman J, Kogner P, Bedoya-Reina OC, Schlisio S, Holmberg J.Proc Natl Acad Sci U S A. 2025 Oct 28;122(43):e2516922122. doi: 10.1073/pnas.2516922122. Epub 2025 Oct 21.PMID: 41118218 Free PMC article. 

Aberrant expression of SLAMF6 constitutes a targetable immune escape mechanism in acute myeloid leukemia.

Sandén C, Landberg N, Peña-Martínez P, Thorsson H, Daga S, Puente-Moncada N, Rodriguez-Zabala M, von Palffy S, Rissler M, Lazarevic V, Juliusson G, Ohlin M, Hyrenius-Wittsten A, Orsmark-Pietras C, Lilljebjörn H, Ågerstam H, Fioretos T.Nat Cancer. 2025 Oct 3. doi: 10.1038/s43018-025-01054-6. Online ahead of print.PMID: 41044242

Addition of hydroxyurea (hydroxycarbamide) enhances the efficacy of fludarabine/cytarabine-based salvage regimens against acute myeloid leukaemia.

Lilienthal I, Tao S, Nilsson C, Leonard E, Zhang R, Sorteberg AL, Fredrikson L, Xagoraris I, Fard SS, Tsesmetzis N, Zachariadis V, Cai H, Sandhow L, Langebäck A, Bohlin A, Tamm KP, Bengtzén S, Schinazi RF, Lehmann S, Kim B, Rassidakis GZ, Qian H, Jädersten M, Herold N.Br J Haematol. 2025 Sep 27. doi: 10.1111/bjh.70180. Online ahead of print.PMID: 41014199

FET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners.

Lindén M, Andersson L, Albatrok H, Canfjorden V, Jonasson E, Grönqvist K, Sjövall D, Jaako P, Crescitelli R, Fagman H, Åman P, Ståhlberg A.Cell Mol Biol Lett. 2025 Sep 23;30(1):107. doi: 10.1186/s11658-025-00792-w.PMID: 40988026 Free PMC article.

Tracing metastatic spread in pediatric solid tumors using copy number and targeted deep sequencing.

Andersson N, Ferro M, Jansson C, Chattopadhyay S, Karlsson J, Gisselsson D.J Pathol. 2025 Nov;267(3):347-365. doi: 10.1002/path.6472. Epub 2025 Sep 23.PMID: 40985487 Free PMC article. 

The Electronic Faces Thermometer Scale (eFTS)-Construct Validity for Pain Assessment in Pediatric Postoperative Care in Sweden.

Höök A, Hylén M, Björk M, Nilsson S, Bai J, Berlin H, Hansson H, Kristjánsdóttir G, Roxner R, Stenström P, Castor C.Paediatr Anaesth. 2025 Sep 22. doi: 10.1111/pan.70056. Online ahead of print.PMID: 40977637

Absolute copy number aware CNV calling of sub-megabase segments in ultra-low coverage single-cell DNA sequencing data.

Kolbeinsdottir S, Zachariadis V, Sommerauer C, Lohi O, Heinäniemi M, Enge M.Nucleic Acids Res. 2025 Sep 5;53(17):gkaf919. doi: 10.1093/nar/gkaf919.PMID: 40973453 Free PMC article.

Targeted ferroptosis induction enhances chemotherapy efficacy in chemoresistant neuroblastoma.

Mañas A, Seger A, Adamska A, Smyrilli K, Siaw JT, Radke K, Muciño-Olmos EA, Bedoya-Reina OC, Esfandyari J, Aaltonen K, Bexell D.NPJ Precis Oncol. 2025 Sep 16;9(1):311. doi: 10.1038/s41698-025-01090-6.PMID: 40957885 Free PMC article.

COVID-19 infection and severity among childhood cancer survivors in Denmark and Sweden: a register-based cohort study with matched population and sibling comparisons.

Louro J, Kampitsi CE, Mogensen H, Erdmann F, Modig K, Nilsson A, Heyman M, Hasle H, Krøyer A, Kenborg L, Hjalgrim H, Feychting M, Tettamanti G.Lancet Reg Health Eur. 2025 Jul 4;55:101363. doi: 10.1016/j.lanepe.2025.101363. eCollection 2025 Aug.PMID: 40950946 Free PMC article. 

Early prediction of subsequent peg-asparaginase inactivation in acute lymphoblastic leukaemia patients-A NOPHO ALL2008 study.

Dam M, Centanni M, Centanni D, Friberg LE, Karlsson MO, Lynggaard LS, Johannsdottir IM, Lepik K, Vaitkeviciene GE, Griskevicius L, Pöyhönen T, Pyörälä M, Jónsson ÓG, Quist-Paulsen P, Schmiegelow K, Christoforaki T, Overgaard U, Hansen SN, Albertsen BK.Br J Haematol. 2025 Sep 7. doi: 10.1111/bjh.70145. Online ahead of print.PMID: 40916350 

Metabolic Profiling Reveals a Glycolytic Shift and an IRG1/Itaconate/NF2L2 Axis Regulating Neurotoxic Oxidative Stress in Inflammatory Microglia.

Engskog-Vlachos P, Engskog MKR, Skandik M, Grabert K, Moruzzi N, St-Pierre MK, Osman AM, Sylaidi T, Blomgren K, Berggren PO, Joseph B.J Neurochem. 2025 Sep;169(9):e70219. doi: 10.1111/jnc.70219.PMID: 40913317 Free PMC article. 

Repurposing Asparaginase Therapy to Target Cisplatin-Resistant Cancer Cells.

Wang J, Pouryaghoub N, Strauss R, Bartek J, Zhang SM, Rudd SG.Fundam Clin Pharmacol. 2025 Oct;39(5):e70044. doi: 10.1111/fcp.70044.PMID: 40784667 Free PMC article.

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